The Cassel saved

Surgery Saved the Day

Valuing “ Lives Saved ” vs . “ Life - Years Saved ”

There is long-standing debate whether to count “lives saved” or “life-years saved” when evaluating policies to reduce mortality risk. Historically, the two approaches have been applied in different domains. Environmental and transportation policies have often been evaluated using lives saved, while life-years saved has been the preferred metric in other areas of public health including medicine...

Reviews and Commentary THE LEGACY OF JOHN C . CASSEL MICHEL

The contributions of John C. Cassel as investigator, scholar and teacher continue to influence contemporary epidemiology, both in the United States and throughout the world. In anticipation of current trends in the teaching and practice of epidemiology, Cassel synthesized the concepts of the social and behavioral sciences as they affect the health of populations. The continuing impact of Cassel...

The Telencephalon Saved by TLC

The telencephalon is one of the most complex parts of the brain, and its patterning is still poorly understood. In this issue of Neuron, describe a novel Wnt antagonist Tlc, a member of the secreted Frizzled-related protein (sFrp) family. Secreted from the anterior boundary of the zebrafish neural plate, Tlc appears to protect the telencephalon from obliteration by a more caudal neural Wnt signal.

Can Game Theory Be Saved? Can Game Theory Be Saved?

Game-theoretic analysis is a well-established part of the toolkit of economic analysis. In crucial respects, however, game theory has failed to deliver on its original promise of generating sharp predictions of behavior in situations where neoclassical microeconomics has little to say. Experience has shown that in most situations, it is possible to tell a game-theoretic story to …t almost any p...